منابع مشابه
CREB downregulation in vascular disease: a common response to cardiovascular risk.
OBJECTIVE To examine the impact of low-density lipoprotein (LDL), an established mediator of atherosclerosis, on the transcription factor cAMP-response element-binding protein (CREB), which is a regulator of vascular smooth muscle cell (VSMC) quiescence. METHODS AND RESULTS VSMC CREB content is diminished in rodent models of diabetes and pulmonary hypertension. We examined aortic CREB content...
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BACKGROUND Nestin was reported to directly contribute to cell proliferation and the intermediate filament protein was detected in vascular smooth muscle cells. In experimental type I diabetes, nestin downregulation in the heart was identified as an incipient pathophysiological event. The following study tested the hypothesis that dysregulation of nestin expression in vascular smooth muscle cell...
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متن کاملAge‐associated downregulation of vasohibin‐1 in vascular endothelial cells
Vasohibin-1 (VASH1) is an angiogenesis-inhibiting factor synthesized by endothelial cells (ECs) and it also functions to increase stress tolerance of ECs, which function is critical for the maintenance of vascular integrity. Here, we examined whether the expression of VASH1 would be affected by aging. We passaged human umbilical vein endothelial cells (HUVECs) and observed that VASH1 was downre...
متن کاملCREB signalling in bipolar disease (Commentary on Gaspar et al.)
Approximately one in 30 individuals across the world suffers from bipolar disorder (BD). With this prevalence, the pathophysiology of BD represents one of the most important unsolved challenges in neuroscience. Although there appears to be a strong hereditary component to the disorder, genome-wide association studies have failed to identify any obvious underlying developmental or signalling pat...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2010
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.109.199133